James Cuffe (1707 – 20 March 1762), of Elmhall and Ballinrobe, was an Irish landowner in County Mayo.
He was the son of Gerald Cuffe, who built Elmhall, and grandson of Sir James Cuffe, who was granted the lands of Ballinrobe in 1667. On 30 April 1731 he married Elizabeth, daughter of Sir Arthur Gore, 2nd Baronet; they were the parents of James Cuffe, 1st Baron Tyrawley.
In 1742 Cuffe succeeded his father-in-law as Member of Parliament for County Mayo in the Irish House of Commons, sitting until 1760.